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1. (WO2017197153) COMBINATION THERAPIES OF HDAC INHIBITORS AND PD-1 INHIBITORS

Pub. No.:    WO/2017/197153    International Application No.:    PCT/US2017/032218
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Fri May 12 01:59:59 CEST 2017
IPC: A61K 31/13
A61K 39/21
A61K 31/136
C07K 14/16
C12Q 1/68
C12Q 1/70
Applicants: HUYA BIOSCIENCE INTERNATIONAL, LLC
Inventors: BISSONNETTE, Reid, P.
ROLLAND, Alain
GILLINGS, Mireille
Title: COMBINATION THERAPIES OF HDAC INHIBITORS AND PD-1 INHIBITORS
Abstract:
Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.