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1. (WO2017197153) COMBINATION THERAPIES OF HDAC INHIBITORS PD-1 INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/197153    International Application No.:    PCT/US2017/032218
Publication Date: 16.11.2017 International Filing Date: 11.05.2017
IPC:
A61K 31/13 (2006.01), A61K 39/21 (2006.01), A61K 31/136 (2006.01), C07K 14/16 (2006.01), C12Q 1/68 (2006.01), C12Q 1/70 (2006.01)
Applicants: HUYA BIOSCIEN INTERNATIONAL, LLC [US/US]; 12531 High Bluff Drive, Suite 138 San Diego, CA 92130 (US)
Inventors: BISSONNETTE, Reid, P.; (US).
ROLLAND, Alain; (GB).
GILLINGS, Mireille; (US)
Agent: PRINCE, Robert; (US)
Priority Data:
62/436,361 19.12.2016 US
62/335,044 11.05.2016 US
Title (EN) COMBINATION THERAPIES OF HDAC INHIBITORS PD-1 INHIBITORS
(FR) POLYTHÉRAPIES D'INHIBITEURS DE HDAC ET D'INHIBITEURS DE PD-1
Abstract: front page image
(EN)Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.
(FR)L'invention concerne des combinaisons qui comprennent un inhibiteur de HDAC et un inhibiteur de PD-1 qui sont utiles pour le traitement du cancer, notamment pour la réduction et/ou la prévention de métastases cancéreuses. La combinaison est également utile pour traiter le cancer qui a été précédemment traité avec un inhibiteur de PD-L1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)