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1. (WO2017197098) DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC COMPLEMENTATION VECTORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/197098    International Application No.:    PCT/US2017/032139
Publication Date: 16.11.2017 International Filing Date: 11.05.2017
IPC:
C12N 15/65 (2006.01), C12N 15/67 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Drive Thousand Oaks, California 91320 (US)
Inventors: KETCHEM, Randal R.; (US).
MCGREW, Jeffrey T.; (US).
FOMINA YADLIN, Dina A.; (US).
MUNRO, Trent P.; (US).
AGRAWAL, Neeraj Jagdish; (US).
DARIS, Kristine M.; (US)
Agent: ANDALIS, Alex A.; (US)
Priority Data:
62/334,966 11.05.2016 US
Title (EN) DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC COMPLEMENTATION VECTORS
(FR) SÉLECTION DIRECTE DE CELLULES EXPRIMANT DES TENEURS ÉLEVÉES EN PROTÉINES HÉTÉROMÈRES À L'AIDE DE VECTEURS DE COMPLÉMENTATION INTRAGÉNIQUE DE GLUTAMINE SYNTHÉTASE
Abstract: front page image
(EN)This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.
(FR)Cette invention concerne le domaine général de l'expression recombinée de polypeptides dans une culture de cellules animales. Plus spécifiquement, l'invention concerne une sélection améliorée de cellules transfectées par des vecteurs modifiés par recombinaison conçus pour exprimer des polypeptides, en particulier des polypeptides hétéromultimères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)