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1. (WO2017197098) DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC COMPLEMENTATION VECTORS

Pub. No.:    WO/2017/197098    International Application No.:    PCT/US2017/032139
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Fri May 12 01:59:59 CEST 2017
IPC: C12N 15/65
C12N 15/67
Applicants: AMGEN INC.
Inventors: KETCHEM, Randal R.
MCGREW, Jeffrey T.
FOMINA YADLIN, Dina A.
MUNRO, Trent P.
AGRAWAL, Neeraj Jagdish
DARIS, Kristine M.
Title: DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC COMPLEMENTATION VECTORS
Abstract:
This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.