WO2017197083 PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

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Publication Number WO/2017/197083

Publication Date 16.11.2017

International Application No. PCT/US2017/032104

International Filing Date 11.05.2017

IPC

CPC

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Applicants

GLOBAL BLOOD THERAPEUTICS, INC. [US]/[US]

Inventors

LI, Zhe
GUZ, Nathan
SHAO, Yiyang
COCUZ, Julieana
FRIESER, Markus
YIANNIKOUROS, George, Petros
LIAO, Liang

Agents

TANNER, Lorna, L.

Priority Data

62/335,583

12.05.2016

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

(FR) PROCÉDÉ DE SYNTHÈSE DE 2-HYDROXY-6-((2- (1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)MÉTHOXY)BENZALDÉHYDE

Abstract

(EN) Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H- pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

(FR) L'invention concerne des procédés de synthèse de 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)méthoxy)benzaldéhyde (également appelé ici composé (I)) ainsi que des intermédiaires utilisés dans lesdits procédés. Le composé (I) se lie à l'hémoglobine et augmente l'affinité de l'oxygène et peut donc être utile pour le traitement de maladies telles que la drépanocytose.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non-condensed pyridines; Hydrogenated derivatives thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
231	Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02	not condensed with other rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non-condensed pyridines; Hydrogenated derivatives thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
231	Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02	not condensed with other rings

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1. WO2017197083 - PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
45	Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61	by reactions not involving the formation of >C = O groups
65	by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups