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1. WO2017197083 - PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

Publication Number WO/2017/197083
Publication Date 16.11.2017
International Application No. PCT/US2017/032104
International Filing Date 11.05.2017
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A61K 31/44 (2006.01)
C07D 231/02 (2006.01)
C07D 401/04 (2006.01)
CPC
C07B 2200/13
C07C 45/65
C07C 47/575
C07D 401/04
Applicants
  • GLOBAL BLOOD THERAPEUTICS, INC. [US/US]; 171 Oyster Point Blvd., Suite 300 South San Francisco, CA 94080, US
Inventors
  • LI, Zhe; US
  • GUZ, Nathan; US
  • SHAO, Yiyang; US
  • COCUZ, Julieana; US
  • FRIESER, Markus; US
  • YIANNIKOUROS, George, Petros; US
  • LIAO, Liang; US
Agents
  • TANNER, Lorna, L.; US
Priority Data
62/335,58312.05.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZALDEHYDE
(FR) PROCÉDÉ DE SYNTHÈSE DE 2-HYDROXY-6-((2- (1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)MÉTHOXY)BENZALDÉHYDE
Abstract
(EN)
Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H- pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.
(FR)
L'invention concerne des procédés de synthèse de 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)méthoxy)benzaldéhyde (également appelé ici composé (I)) ainsi que des intermédiaires utilisés dans lesdits procédés. Le composé (I) se lie à l'hémoglobine et augmente l'affinité de l'oxygène et peut donc être utile pour le traitement de maladies telles que la drépanocytose.
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