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1. (WO2017197056) BROMODOMAIN TARGETING DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/197056 International Application No.: PCT/US2017/032053
Publication Date: 16.11.2017 International Filing Date: 10.05.2017
IPC:
C07D 471/04 (2006.01) ,C07D 471/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants: C4 THERAPEUTICS, INC.[US/US]; 675 W. Kendall Street Cambridge, MA 02142, US
Inventors: PHILLIPS, Andrew, J.; US
NASVESCHUK, Chris, G.; US
HENDERSON, James, A.; US
LIANG, Yanke; US
FITZGERALD, Mark, E.; US
MICHAEL, Ryan, E.; US
Agent: BELLOWS, Brent, R.; US
KNOWLES, Sherry, M.; US
Priority Data:
62/334,41110.05.2016US
Title (EN) BROMODOMAIN TARGETING DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
(FR) DÉGRONIMÈRES CIBLANT UN BROMODOMAINE POUR LA DÉGRADATION DE PROTÉINES CIBLES
Abstract:
(EN) This invention provides a Degronimer that has an E3 Ubiquitin Ligase targeting moiety (Degron) that can be linked to a Targeting Ligand for a bromodomain protein selected for in vivo degradation to achieve a therapeutic effect, and methods of use and compositions thereof as well as methods for their preparation.
(FR) La présente invention concerne un dégronimère qui possède une fraction ciblant l'ubiquitine Ligase E3 (Degron) qui peut être liée à un Ligand de ciblage pour une protéine de bromodomaine sélectionnée pour une dégradation in vivo en vue d’obtenir un effet thérapeutique, et des méthodes d'utilisation, des compositions de ceux-ci ainsi que des procédés pour leur préparation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)