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1. (WO2017197036) SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/197036 International Application No.: PCT/US2017/032031
Publication Date: 16.11.2017 International Filing Date: 10.05.2017
IPC:
A61K 31/527 (2006.01) ,C07D 209/54 (2006.01) ,C07D 209/96 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
527
spiro-condensed
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
54
Spiro-condensed
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
96
Spiro-condensed ring systems
Applicants: C4 THERAPEUTICS, INC.[US/US]; 675 W. Kendall Street Cambridge, MA 02142, US
Inventors: PHILLIPS, Andrew, J.; US
NASVESCHUK, Chris, G.; US
HENDERSON, James, A.; US
LIANG, Yanke; US
LAZARSKI, Kiel; US
MICHAEL, Ryan, E.; US
Agent: BELLOWS, Brent, R.; US
KNOWLES, Sherry, M.; US
Priority Data:
62/334,13010.05.2016US
Title (EN) SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
(FR) DÉGRONIMÈRES SPIROCYCLIQUES POUR LA DÉGRADATION DE PROTÉINES CIBLES
Abstract:
(EN) This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
(FR) L'invention concerne des composés qui comprennent des fractions ciblant l'ubiquitine ligase E3 spirocyclique (Dégrons), qui peuvent être utilisés tels quels ou liés à un ligand ciblant une protéine qui a été sélectionnée pour une dégradation in vivo, et des méthodes d'utilisation et des compositions associées ainsi que des procédés pour leur préparation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)