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1. (WO2017197016) MELATONIN-BASED NASAL COMPOSITIONS AND USES THEREOF
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Pub. No.: WO/2017/197016 International Application No.: PCT/US2017/032008
Publication Date: 16.11.2017 International Filing Date: 10.05.2017
IPC:
A61K 9/00 (2006.01) ,A61K 31/4045 (2006.01) ,A61K 31/405 (2006.01) ,A61P 25/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
4045
Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
Applicants: THE LESTER SMITH MEDICAL RESEARCH INSTITUTE, LLC[US/US]; 1001 Fannin Street Suite 3850 Houston, TX 77002, US
Inventors: CORONADO, Ramon; US
Agent: ANDERSON, Kristopher, Lance; US
Priority Data:
62/334,12210.05.2016US
Title (EN) MELATONIN-BASED NASAL COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS DESTINÉES À UNE ADMINISTRATION PAR VOIE NASALE À BASE DE MÉLATONINE, ET LEURS UTILISATIONS
Abstract:
(EN) Disclosed is an improved composition characterized in containing a combination of melatonin and 5-HTP in a nasal administration for the rapid treatment of insomnia, anxiety, and related disorders in mammals, including humans. The present invention relates also to a pharmaceutical composition comprising 5-HTP and melatonin which utilizes the known effects of two substances to provide sleep improvement, relaxation, and reduced anxiety via rapid delivery of the combination, via nasal administration, for short-term alleviation of sleep disorder and anxiety-related symptoms. The combined effects of 5-HTP and melatonin in the present invention provide a short-term increase in blood plasma levels of melatonin while simultaneously increasing the production of serotonin for purposes of achieving natural melatonin biosynthesis in combination with the increased melatonin content in blood plasma.
(FR) L'invention concerne une composition améliorée caractérisée en ce qu'elle contient une combinaison de mélatonine et de 5-HTP dans un produit à administrer par voie voie nasale, destinée au traitement rapide de l'insomnie, de l'anxiété et de troubles associés chez le mammifère, y compris l'homme. La présente invention concerne également une composition pharmaceutique comprenant du 5-HTP et de la mélatonine, qui utilise les effets connus de ces deux substances en vue de procurer une amélioration du sommeil, une relaxation et une diminution de l'anxiété par administration rapide de la combinaison, par voie nasale, de manière à soulager rapidement les troubles du sommeil et les symptômes liés à l'anxiété. Les effets combinés du 5-HTP et de la mélatonine selon la présente invention obtiennent une augmentation rapide des taux plasmatiques de mélatonine tout en augmentant simultanément la production de sérotonine de manière à réaliser une biosynthèse de la mélatonine naturelle en combinaison avec l'augmentation de la teneur en mélatonine dans le plasma sanguin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)