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1. (WO2017196872) ORTHOGONAL APPROACH TO INTEGRATE INDEPENDENT OMIC DATA

Pub. No.:    WO/2017/196872    International Application No.:    PCT/US2017/031799
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Wed May 10 01:59:59 CEST 2017
IPC: G06F 19/18
Applicants: WAYNE STATE UNIVERSITY
Inventors: DRAGHICI, Sorin
NGUYEN, Tin Chi
Title: ORTHOGONAL APPROACH TO INTEGRATE INDEPENDENT OMIC DATA
Abstract:
Methods and devices for integrating a plurality of data types are provided. The methods include obtaining, via a processor, a plurality of datasets of a given type including measurements of one or more quantitative variables related to a phenotype comparison, and a plurality of datasets of a different type including measurements of one or more quantitative variables related to the same phenotype comparison; calculating, via the processor, effect sizes of the variables of the first type, effect sizes of the variables of the second type, and global p-values for the first and second data types; and combining, via the processor, the effect sizes and/or the global p-values to identify the variables of either type that are relevant in the given phenotype comparison.