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1. (WO2017196860) ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY

Pub. No.:    WO/2017/196860    International Application No.:    PCT/US2017/031779
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Wed May 10 01:59:59 CEST 2017
IPC: A61B 8/00
A61B 8/12
A61M 25/10
G01N 29/00
G01N 29/06
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: HSIAI, Tzung, K.
TAI, Yu-Chong
PACKARD, Rene R. Sevag
LUO, Yuan
ABIRI, Parinaz
MA, Jianguo
Title: ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY
Abstract:
The present invention provides devices for characterizing regions of tissue and methods for using the same. The devices are capable of locating, identifying, and characterizing tissue regions of interest in vivo. In one embodiment, the devices are ultrasound-guided. In one embodiment, the devices use characterize regions of tissue using electrical impedance spectroscopy (EIS) sensors. In one aspect, the devices are useful in predicting plaque rupture, such as by determining the level of oxidized low density lipoprotein (oxLDL) and macrophage/foam cells present in an atheroma. In one aspect, the devices are useful in identifying metabolically active atherosclerotic lesions that are angiographically invisible.