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|1. (WO2017196860) ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY|
|Applicants:||THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|Inventors:||HSIAI, Tzung, K.
PACKARD, Rene R. Sevag
|Title:||ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY|
The present invention provides devices for characterizing regions of tissue and methods for using the same. The devices are capable of locating, identifying, and characterizing tissue regions of interest in vivo. In one embodiment, the devices are ultrasound-guided. In one embodiment, the devices use characterize regions of tissue using electrical impedance spectroscopy (EIS) sensors. In one aspect, the devices are useful in predicting plaque rupture, such as by determining the level of oxidized low density lipoprotein (oxLDL) and macrophage/foam cells present in an atheroma. In one aspect, the devices are useful in identifying metabolically active atherosclerotic lesions that are angiographically invisible.