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Machine translation
1. (WO2017196598) ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/196598    International Application No.:    PCT/US2017/030760
Publication Date: 16.11.2017 International Filing Date: 03.05.2017
IPC:
A61K 47/68 (2017.01), A61P 35/00 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543 (US)
Inventors: CONG, Qiang; (US).
GANGWAR, Sanjeev; (US).
RANGAN, Vangipuram S.; (US).
SUNG, Mei-Chen; (US)
Agent: CHAO, Yuan; (US).
CLAUSS, Isabelle M.; (US).
DELAUNEY, Ashton J.; (US).
FARQUHARSON-TORRES, Serena; (US).
GOLIAN, Paul D.; (US).
GREENBLATT, Gary D.; (US).
GUO, Z. Angela; (US).
HADAD, Henry; (US).
HAI, Bing; (US).
JACOBSEN, Barry; (US).
KORSEN, Elliott; (US).
LIU, Hong; (US).
LU, Yong; (US).
PARLET, Nickki L.; (US).
SUN, Jing G.; (US).
VANATTEN, Mary K.; (US).
VOM WEGE, Julia; (US).
WALSH, Brian J.; (US).
EPPERSON, James; (US).
MINGO, Pamela A.; (US).
BELLOMY, Gregory R.; (US)
Priority Data:
62/333,924 10.05.2016 US
Title (EN) ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY
(FR) CONJUGUÉS ANTICORPS-MÉDICAMENTS D'ANALOGUES DE LA TUBULYSINE À STABILITÉ AMÉLIORÉE
Abstract: front page image
(EN)The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.
(FR)Le constituant médicamenteux d'un conjugué anticorps-médicament ayant une structure selon la formule (II), dans laquelle Ab, m, n, R1, R2, R3, R4, et R5 sont tels que définis dans la description, présente une stabilité étonnamment améliorée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)