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1. (WO2017195224) RHO GTPASE ACTIVATING BACTERIAL TOXINS FOR USE IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM BY MUCOSAL ADMINISTRATION

Pub. No.:    WO/2017/195224    International Application No.:    PCT/IT2016/000120
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Tue May 10 01:59:59 CEST 2016
IPC: A61K 38/16
A61P 25/00
Applicants: ISTITUTO SUPERIORE DI SANITA'
Inventors: DIANA, Giovanni
Title: RHO GTPASE ACTIVATING BACTERIAL TOXINS FOR USE IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM BY MUCOSAL ADMINISTRATION
Abstract:
The present invention concerns Rho GTPase activating bacterial toxins for use in treatment of cognitive impairment and neurodegenerative diseases such as Parkinson's disease by topical ocular, nasal or enteral administration, wherein said Rho GTPase activating protein toxins are chosen from the group consisting of Cytotoxic Necrotizing Factor 1 (CNF1 ) and Cytotoxic Necrotizing Factor 2 (CNF2).