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1. (WO2017195216) CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/195216 International Application No.: PCT/IN2017/050167
Publication Date: 16.11.2017 International Filing Date: 08.05.2017
IPC:
C07C 259/06 (2006.01) ,C07D 261/08 (2006.01) ,C07D 239/26 (2006.01) ,C07D 401/04 (2006.01) ,C07D 403/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 413/14 (2006.01) ,C07C 259/08 (2006.01) ,C07C 259/10 (2006.01) ,C07D 231/12 (2006.01) ,C07D 233/64 (2006.01) ,A61K 31/165 (2006.01) ,A61P 35/00 (2006.01) ,C07D 401/12 (2006.01) ,C07D 413/12 (2006.01) ,C07D 417/12 (2006.01) ,C07D 249/04 (2006.01) ,C07D 487/04 (2006.01) ,C07D 205/04 (2006.01) ,C07D 211/26 (2006.01) ,C07D 211/58 (2006.01)
Applicants: JUBILANT BIOSYS LIMITED[IN/IN]; #96, Industrial Suburb, 2nd Stage, Yeshwanthpur Bangalore 560022, IN
Inventors: RAJAGOPAL, Sridharan; IN
HALLUR, Mahanandeesha S.; IN
DEWANG, Purushottam; IN
MURUGAN, Kannan; IN
KUMAR C.H., Durga Prasanna; IN
IYER, Pravin; IN
MULAKALA, Chandrika; IN
SIVANANDHAN, Dhanalakshmi; IN
NAIR, Sreekala; IN
ZAINUDDIN, Mohd.; IN
TANTRY, Subramanyam Janardhan; IN
GAJENDRAN, Chandru; IN
RAJAGOPAL, Sriram; IN
Agent: LAKSHMIKUMARAN, Malathi; IN
PHILLIPS, Prashant; IN
PANDEYA, Jaya; IN
RAE, Konpal; IN
SRINIVASAN, T; IN
Priority Data:
20164101612909.05.2016IN
Title (EN) CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS
(FR) COMPOSÉS CYCLOPROPYL-AMIDES UTILISÉS COMME INHIBITEURS DOUBLES DE LSD1/HDAC
Abstract: front page image
(EN) The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.
(FR) La présente invention concerne de nouveaux composés de formule générale (I), leurs analogues, leurs formes tautomères, leurs stéréoisomères, leurs polymorphes, leurs hydrates, leurs solvates, leurs sels pharmaceutiques acceptables, des compositions pharmaceutiques, des métabolites et des promédicaments correspondants. Ces composés sont capables d'inhiber à la fois LSD et HDAC et sont utilisés comme agents thérapeutiques ou d'atténuation des maladies impliquées dans la croissance cellulaire, par exemple les tumeurs malignes, la schizophrénie, la maladie d'Alzheimer, la maladie de Parkinson et similaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)