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1. (WO2017195086) SALTS OF N,N-DIMETHYLBIGUANIDE AND PREPARATION METHODS THEREOF

Pub. No.:    WO/2017/195086    International Application No.:    PCT/IB2017/052654
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Tue May 09 01:59:59 CEST 2017
IPC: C07C 279/26
Applicants: SARATH KUMAR, Kamavarapu
Inventors: SARATH KUMAR, Kamavarapu
Title: SALTS OF N,N-DIMETHYLBIGUANIDE AND PREPARATION METHODS THEREOF
Abstract:
The present invention provides novel metformin salts, method of preparing, and pharmaceutical compositions containing the same. The metformin sesquihydrochloride and metformin dihydrochloride according to the present invention has improved pharmacological effects as compared with metformin monohydrochloride and is capable of achieving a therapeutic purpose by administering a reduced amount of metformin. The metformin sesquihydrochloride and dihydrochloride has excellent physicochemical properties, such as solubility, stability, non-hygroscopic and good flow characteristics.