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1. (WO2017195086) SALTS OF N,N-DIMETHYLBIGUANIDE AND PREPARATION METHODS THEREOF
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Pub. No.: WO/2017/195086 International Application No.: PCT/IB2017/052654
Publication Date: 16.11.2017 International Filing Date: 08.05.2017
IPC:
C07C 279/26 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
279
Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20
containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24
Y being a hetero atom
26
X and Y being nitrogen atoms, i.e. biguanides
Applicants: SARATH KUMAR, Kamavarapu[IN/IN]; IN
Inventors: SARATH KUMAR, Kamavarapu; IN
Priority Data:
20164101635110.05.2016IN
20164101635210.05.2016IN
Title (EN) SALTS OF N,N-DIMETHYLBIGUANIDE AND PREPARATION METHODS THEREOF
(FR) SELS DE N, N-DIMÉTHYLBIGUANIDE ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
Abstract:
(EN) The present invention provides novel metformin salts, method of preparing, and pharmaceutical compositions containing the same. The metformin sesquihydrochloride and metformin dihydrochloride according to the present invention has improved pharmacological effects as compared with metformin monohydrochloride and is capable of achieving a therapeutic purpose by administering a reduced amount of metformin. The metformin sesquihydrochloride and dihydrochloride has excellent physicochemical properties, such as solubility, stability, non-hygroscopic and good flow characteristics.
(FR) La présente invention concerne de nouveaux sels de metformine, leur procédé de préparation et des compositions pharmaceutiques les contenant. Le sesquichlorhydrate de metformine et le dichlorhydrate de metformine selon la présente invention ont des effets pharmacologiques améliorés par rapport au monochlorhydrate de metformine et sont capables d'obtenir un effet thérapeutique par administration d'une quantité réduite de metformine. Le sesquichlorhydrate de metformine et le dichlorhydrate présentent d'excellentes propriétés physicochimiques, telles que la solubilité, la stabilité, une non-hygroscopicité et de bonnes caractéristiques d'écoulement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)