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1. (WO2017194596) MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/194596    International Application No.:    PCT/EP2017/061162
Publication Date: 16.11.2017 International Filing Date: 10.05.2017
IPC:
C07K 14/31 (2006.01), G01N 33/68 (2006.01)
Applicants: GE HEALTHCARE BIOPROCESS R&D AB [SE/SE]; Björkgatan 30 751 84 Uppsala (SE)
Inventors: RODRIGO, Gustav, José; (SE).
BJORKMAN, Tomas; (SE).
ANDER, Mats; (SE)
Agent: LARSSON, Anders; GE HEALTHCARE BIOPROCESS R&D AB Patent Department, Björkgatan 30 751 84 Uppsala (SE).
ALDENBÄCK, Ulla; (SE).
LARSSON, Anders; (SE).
SÖRBY, Lennart; (SE)
Priority Data:
1608229.9 11.05.2016 GB
1608232.3 11.05.2016 GB
15/282,367 30.09.2016 US
Title (EN) MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
(FR) POLYPEPTIDES MUTANTS LIANT L'IMMUNOGLOBULINE
Abstract: front page image
(EN)An Fc-binding polypeptide of improved alkali stability, comprising a mutant of aparental Fc- binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52, wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO: 4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.
(FR)L'invention concerne un polypeptide de liaison à Fc ayant une stabilité améliorée par rapport aux alcalis, comprenant un mutant d'un domaine parental de liaison à Fc de la protéine A de Staphylococcus (SpA), tel que défini par SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 22, SEQ ID NO: 51 ou SEQ ID NO: 52, au moins le résidu asparagine ou sérine à la position correspondant à la position 11 dans SEQ ID NO: 4 à 7 ayant été muté en un acide aminé sélectionné dans le groupe constitué par l'acide glutamique, la lysine, la tyrosine, la thréonine, la phénylalanine, la leucine, l'isoleucine, le tryptophane, la méthionine, la valine, l'alanine, l'histidine et l'arginine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)