Search International and National Patent Collections

1. (WO2017194576) HOT MELT EXTRUSION COMPOSITION USING DIRECT COMPRESSIBLE EXCIPIENT AS PLASTICIZER

Pub. No.:    WO/2017/194576    International Application No.:    PCT/EP2017/061126
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Thu May 11 01:59:59 CEST 2017
IPC: A61K 9/14
A61K 47/26
A61K 31/405
Applicants: MERCK PATENT GMBH
Inventors: LUBDA, Dieter
ZHENG, Mengyao
ELIA, Alessandro
DI GALLO, Nicole
Title: HOT MELT EXTRUSION COMPOSITION USING DIRECT COMPRESSIBLE EXCIPIENT AS PLASTICIZER
Abstract:
The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties,achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.