Search International and National Patent Collections

1. (WO2017194568) TREATMENT REGIMEN USING ANTI-MUC1 MAYTANSINOID IMMUNOCONJUGATE ANTIBODY FOR THE TREATMENT OF TUMORS

Pub. No.:    WO/2017/194568    International Application No.:    PCT/EP2017/061103
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Wed May 10 01:59:59 CEST 2017
IPC: A61K 47/50
A61P 35/00
Applicants: SANOFI
Inventors: ASSADOURIAN, Sylvie
COHEN, Patrick
FAGNIEZ, Nathalie
TELLIER, Alexia
Title: TREATMENT REGIMEN USING ANTI-MUC1 MAYTANSINOID IMMUNOCONJUGATE ANTIBODY FOR THE TREATMENT OF TUMORS
Abstract:
The present invention concerns a conjugate comprising (i) a cell binding agent which binds to the human mucin-1 (MUC1) glycoprotein, linked to (ii) at least one cytotoxic agent, for use in a method for treating cancer, wherein the method comprises at least two cycles, wherein, for each cycle, the conjugate is administered at a dose corresponding to that of an administration schedule of at least 60 mg/m2 every week of the cycle, and wherein the conjugate is administered at least two times during each cycle.