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1. (WO2017194442) ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND A TENASCIN BINDING MOIETY

Pub. No.:    WO/2017/194442    International Application No.:    PCT/EP2017/060870
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Tue May 09 01:59:59 CEST 2017
IPC: C07K 16/24
C07K 14/715
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: AMANN, Maria
BRUENKER, Peter
CLAUS, Christina
FERRARA KOLLER, Claudia
GRAU-RICHARDS, Sandra
KLEIN, Christian
LEVITSKI, Viktor
MOESSNER, Ekkehard
UMAÑA, Pablo
Title: ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND A TENASCIN BINDING MOIETY
Abstract:
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (Tn C) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.