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|1. (WO2017194442) ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND A TENASCIN BINDING MOIETY|
|Applicants:||F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
FERRARA KOLLER, Claudia
|Title:||ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND A TENASCIN BINDING MOIETY|
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (Tn C) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.