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1. (WO2017194002) CRYSTAL FORM OF BREXPIPRAZOLE AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2017/194002    International Application No.:    PCT/CN2017/084171
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Sat May 13 01:59:59 CEST 2017
IPC: C07D 409/12
Applicants: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD
浙江华海药业股份有限公司
SHANGHAI AOBO PHARMTECH, INC., LTD.
上海奥博生物医药技术有限公司
Inventors: JIAO, Yinglu
焦英陆
LI, Handa
李函达
WANG, Boyu
汪博宇
HUANG, Luning
黄鲁宁
CHEN, Xi
陈茜
GU, Hong
顾虹
Title: CRYSTAL FORM OF BREXPIPRAZOLE AND PREPARATION METHOD THEREFOR
Abstract:
Disclosed are a crystal form of Brexpiprazole and a preparation method therefor. The X-ray powder diffraction pattern, which is detected with Cu-K α radiation, of the crystal form of Brexpiprazole has characteristic peaks at the positions where 2θ is about 9.1±0.2, 15.2±0.2, 15.7±0.2, 17.6±0.2, 18.1±0.2, and 24.4±0.2. The crystal form I of Brexpiprazole has a high purity, good stability and good reproducibility, and is suitable for industrial production.