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1. (WO2017193913) FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2017/193913    International Application No.:    PCT/CN2017/083630
Publication Date: Fri Nov 17 00:59:59 CET 2017 International Filing Date: Wed May 10 01:59:59 CEST 2017
IPC: C07F 9/6558
C07C 215/10
C07C 213/08
Applicants: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.
浙江华海药业股份有限公司
SHANGHAI AOBO PHARMTECH, INC., LTD.
上海奥博生物医药技术有限公司
Inventors: ZHANG, Jicheng
张继承
LI, Zeng
栗增
HUANG, Luning
黄鲁宁
CHEN, Qian
陈茜
TAO, Anping
陶安平
GU, Hong
顾虹
Title: FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR
Abstract:
Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups; IV-A: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups, and R1 and R2 are not both benzyl groups.