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1. (WO2017193913) FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/193913    International Application No.:    PCT/CN2017/083630
Publication Date: 16.11.2017 International Filing Date: 09.05.2017
IPC:
C07F 9/6558 (2006.01), C07C 215/10 (2006.01), C07C 213/08 (2006.01)
Applicants: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. [CN/CN]; Xunqiao, Linhai Zhejiang 317024 (CN).
SHANGHAI AOBO PHARMTECH, INC., LTD. [CN/CN]; No. 538, Cailun Road, Zhangjiang High-Tech Park, Pudong Shanghai 201203 (CN)
Inventors: ZHANG, Jicheng; (CN).
LI, Zeng; (CN).
HUANG, Luning; (CN).
CHEN, Qian; (CN).
TAO, Anping; (CN).
GU, Hong; (CN)
Agent: BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE; 5/F., Tower A, GT International Center, Jia 3 Yongandongli Jianguomenwai Ave., Chaoyang District Beijing 100022 (CN)
Priority Data:
201610300890.7 09.05.2016 CN
Title (EN) FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR
(FR) INTERMÉDIAIRE PHOSPHATE DE FOSAPRÉPITANT ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 一种福沙匹坦磷酸酯中间体及其制备方法
Abstract: front page image
(EN)Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups; IV-A: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups, and R1 and R2 are not both benzyl groups.
(FR)L'invention concerne un procédé de préparation d'un intermédiaire phosphate de fosaprépitant (IV), un intermédiaire phosphate de fosaprépitant (IV-A) et un procédé (AA) de préparation de fosaprépitant diméglumine à l'aide de l'intermédiaire (IV-A). IV: R1 et R2 sont indépendamment sélectionnés parmi des groupes alkyle en C1-C7 ou des groupes benzyle; IV-A: R1 et R2 sont indépendamment sélectionnés parmi des groupes alkyle en C1-C7 ou des groupes benzyle, et R1 et R2 ne sont pas tous les deux des groupes benzyle.
(ZH)提供一种福沙匹坦磷酸酯中间体(IV)的制备方法、福沙匹坦磷酸酯中间体(IV-A)以及使用中间体(IV-A)制备福沙匹坦二甲葡胺的方法(AA),IV:R 1、R 2独立地选自C1-C7烷基或苄基; IV-A:R 1、R 2独立地选自C1-C7烷基或苄基,并且R 1、R 2不同时为苄基。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)