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|1. (WO2017193913) FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR|
|Applicants:||ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.
SHANGHAI AOBO PHARMTECH, INC., LTD.
|Title:||FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR|
Provided are a fosaprepitant phosphate intermediate (IV) preparation method, a fosaprepitant phosphate intermediate (IV-A) and a method (AA) for preparing fosaprepitant dimeglumine by using the intermediate (IV-A). IV: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups; IV-A: R1 and R2 are independently selected from C1-C7 alkyl groups or benzyl groups, and R1 and R2 are not both benzyl groups.