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1. (WO2017193180) ISATIN-DERIVED COMPOUNDS, USE OF THE COMPOUNDS FOR THE TREATMENT OF AIDS AND METHOD OF TREATMENT USING THESE COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/193180    International Application No.:    PCT/BR2016/000050
Publication Date: 16.11.2017 International Filing Date: 10.05.2016
IPC:
C07D 405/14 (2006.01), C07D 403/06 (2006.01), C07D 209/34 (2006.01), A61K 31/513 (2006.01), A61K 31/4192 (2006.01), A61P 31/18 (2006.01), A61P 31/12 (2006.01)
Applicants: FUNDAÇÃO OSWALDO CRUZ (FIOCRUZ) - SUPERINTENDÊNCIA DE PLANEJAMENTO [BR/BR]; Avenida Brasil 4365 Manguinhos 21045-900 Rio de Janeiro, RJ (BR)
Inventors: BOECHAT, Nubia; (BR).
BASTOS, Mõnica Macedo; (BR).
LOPES E SOUZA, Thiago Moreno; (BR).
LEITE, Débora Inácio; (BR).
BERNARDINO, Alice Maria Rolim; (BR)
Agent: KASZNAR LEONARDOS PROPRIDADE INTELECTUAL; Rua Teófilo Otoni 63, 5th 8th floors CEP: 20090-080, Rio de Janeiro, RJ (BR)
Priority Data:
Title (EN) ISATIN-DERIVED COMPOUNDS, USE OF THE COMPOUNDS FOR THE TREATMENT OF AIDS AND METHOD OF TREATMENT USING THESE COMPOUNDS
(FR) COMPOSÉS DÉRIVÉS D'ISATINE, UTILISATION DE CES COMPOSÉ DANS LE TRAITEMENT DU SIDA ET MÉTHODE DE TRAITEMENT FAISANT APPEL AUXDITS COMPOSÉS
(PT) COMPOSTOS DERIVADOS DE ISATINA, USO DOS COMPOSTOS NO TRATAMENTO DE AIDS E MÉTODO DE TRATAMENTO USANDO DITOS COMPOSTOS
Abstract: front page image
(EN)The present invention relates to HIV-inhibiting compounds consisting of isatin derivatives of formulae I, II and III, as represented below (formulae I, II and III), wherein, in the formulae I, II and III, R1 is selected from H, CH3 or Cl, R2 is selected from one of the following radicals: zidovudine, amprenavir or an acyclic phosphonate chain, these compounds being represented below. The present invention also relates to the use and to the treatment method using the compounds of formulae I, II and III. The compounds according to the present invention are also used for the treatment of infection caused by HBV or co-infections caused by HIV and HBV.
(FR)La présente invention concerne des composés inhibiteurs du VIH, comprenant des dérivés d'isatine de formule I, II et III, tels que représentés comme suit (formules I, II et II). Dans les formules I, Ii et III, R1 est choisi parmi H, CH3 ou Cl, R2 est choisi parmi les radicaux suivants : zidovudine, amprénavir ou une chaîne phosphonate acyclique, représentés comme suit. La présente invention concerne également leur utilisation et une méthode de traitement faisant appel à ces composés de formules I, II et III. Les composés de la présente invention sont également utilisés dans le traitement d'une infection causée par le VHB ou dans la co-infection causée par le VIH et le VHB.
(PT)A presente invenção se refere a compostos inibidores do HIV consistindo de derivados de isatina de fórmulas I, II e III, conforme representados a seguir (fórmulas I, II e III) onde nas fórmulas I, II e III, R1 é selecionado dentre H, CH3 ou Cl R2 é selecionado dentre um dos seguintes radicais: zidovudina, amprenavir ou uma cadeia fosfonato acíclica, representados a seguir. A presente invenção também consiste do uso e do método de tratamento usando os compostos de fórmulas I, II e III. Os compostos da presente invenção também são usados no tratamento de uma infecção causada pelo HBV ou na coinfecção causada pelo HIV e HBV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)