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1. (WO2017193101) DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA

Pub. No.:    WO/2017/193101    International Application No.:    PCT/US2017/031449
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Sat May 06 01:59:59 CEST 2017
IPC: A61K 39/40
C07K 16/00
C07K 16/12
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
INOVIO PHARMACEUTICALS, INC.
Inventors: WEINER, David
PATEL, Ami
YAN, Jian
Title: DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA
Abstract:
Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.