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1. (WO2017193081) SPHERICAL NUCLEIC ACID TLR9 AGONISTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/193081 International Application No.: PCT/US2017/031419
Publication Date: 09.11.2017 International Filing Date: 05.05.2017
IPC:
C12N 15/117 (2010.01) ,A61K 9/127 (2006.01)
Applicants: EXICURE, INC.[US/US]; 8045 Lamon Avenue Suite 410 Skokie, IL 60077-5318, US
Inventors: ANDERSON, Bart; US
NALLAGATLA, Subbarao; US
KANG, Richard; US
KANDIMALLA, Ekambar; US
Agent: LOCKHART, Helen, C.; US
Priority Data:
62/333,07406.05.2016US
Title (EN) SPHERICAL NUCLEIC ACID TLR9 AGONISTS
(FR) AGONISTES DE TLR9 À ACIDE NUCLÉIQUE SPHÉRIQUE
Abstract: front page image
(EN) Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.
(FR) Des aspects de l'invention concernent des compositions d'acides nucléiques sphériques (SNA) composées d'un liposome ou d'un complexe lipoplexe ayant une enveloppe oligonucléotidique avec des oligonucléotides CpG positionnés sur l'extérieur du liposome ou du lipoplexe. L'invention concerne également des procédés de traitement de sujets et d'induction de l'expression de cytokine chez un sujet à l'aide des compositions décrites ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)