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1. (WO2017193059) SYSTEMS AND METHODS FOR TARGETING CANCER CELLS
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Pub. No.: WO/2017/193059 International Application No.: PCT/US2017/031389
Publication Date: 09.11.2017 International Filing Date: 05.05.2017
IPC:
A61K 35/14 (2015.01) ,C12N 5/0783 (2010.01) ,C07K 14/725 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607, US
THE TRUSTEES OF PRINCETON UNIVERSITY[US/US]; 87 Prospect Avenue, Third Floor Princeton, New Jersey 08544, US
THE SIMONS FOUNDATION, INC.[US/US]; 160 Fifth Avenue, 7th Floor New York, New York 10010, US
Inventors: LIM, Wendell A.; US
TROYANSKAYA, Olga G.; US
VANDERSLUIS, Benjamin; US
DANNENFELSER, Ruth; US
Agent: GUEDELHOEFER, Otto C.; US
Priority Data:
62/333,10606.05.2016US
Title (EN) SYSTEMS AND METHODS FOR TARGETING CANCER CELLS
(FR) SYSTÈMES ET PROCÉDÉS DE CIBLAGE DE CELLULES CANCÉREUSES
Abstract:
(EN) The present disclosure provides an immune cell genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a system two antigen-triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a method of killing a target cancer cell, using a genetically modified immune cell or a system of the present disclosure. The present disclosure provides a computational method to identify target antigen pairs on a cancer cell.
(FR) La présente invention concerne une cellule immunitaire génétiquement modifiée pour produire deux polypeptides déclenchés par un antigène, chacun reconnaissant un antigène de surface cellulaire différent. La présente invention concerne un système de deux polypeptides déclenchés par un antigène, reconnaissant chacun un antigène de surface cellulaire différent. La présente invention concerne un procédé de destruction d'une cellule cancéreuse cible, à l'aide d'une cellule immunitaire génétiquement modifiée ou d'un système de la présente invention. La présente invention concerne un procédé informatique permettant d'identifier des paires d'antigènes cibles sur une cellule cancéreuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)