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1. WO2017193008 - METHODS OF DIAGNOSING AND TREATING CANCER WITH MICRORNAS

Publication Number WO/2017/193008
Publication Date 09.11.2017
International Application No. PCT/US2017/031324
International Filing Date 05.05.2017
IPC
A61K 31/7052 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61K 31/7105 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
C12N 2310/141
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2310Structure or type of the nucleic acid
10Type of nucleic acid
14interfering N.A.
141MicroRNAs, miRNAs
Applicants
  • CEDARS-SINAI MEDICAL CENTER [US]/[US]
  • THE SECOND MILITARY MEDICAL UNIVERSITY [CN]/[CN]
Inventors
  • CHUNG, Leland W.K.
  • WANG, Fubo
  • SUN, Yinghao
Agents
  • HUBER, Linda B.
  • BIRKENEDER, Erik J.
  • CHEN, Stephen, W.
  • COSTELLIA, Jeffrey
  • EISENSTEIN, Ronald, I.
  • GARETTO, Janet, M.
  • GATZ, Robert
  • KIM, Sean
  • LEVY, Seth D.
  • MATTAN-HUNG, Natalia
  • PROMMER, Peter J.
  • RESNICK, David S.
  • RITCHIE,, David B.
  • SWIATEK, Maria
  • TANG, Wayne L.
  • VAKHARIA-RAO, Hema
  • HAYES, Jennifer
Priority Data
62/333,01806.05.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF DIAGNOSING AND TREATING CANCER WITH MICRORNAS
(FR) MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER À L'AIDE DE MICROARN
Abstract
(EN)
Described herein are methods of treating and diagnosing cancer, as well as selecting a cancer treatment for a subject in need thereof. In particular, prostate and metastatic cancer are treated or diagnosed. The treatment can comprise administering an miRNA or miRNA mimics described herein to a patient in need thereof. The diagnostic can comprise measuring the miRNA expression levels, as described herein.
(FR)
L'invention concerne des méthodes de traitement et de diagnostic du cancer, ainsi que de sélection d'un traitement anticancéreux pour un sujet en ayant besoin. En particulier, le cancer de la prostate et le cancer métastatique sont traités ou diagnostiqués. Le traitement peut comprendre l'administration d'un miARN ou d'analogues de miARN décrits ici à un patient en ayant besoin. Le diagnostic peut comprendre la mesure des niveaux d'expression du miARN, comme décrit ici.
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