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1. (WO2017192959) THERAPEUTICALLY MODULATING APOB AND APOAI

Pub. No.:    WO/2017/192959    International Application No.:    PCT/US2017/031240
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Sat May 06 01:59:59 CEST 2017
IPC: A61K 31/713
A61K 48/00
C07H 21/04
C12N 15/113
Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
HUSSAIN, M., Mahmood
ZHOU, Liye
Inventors: HUSSAIN, M., Mahmood
ZHOU, Liye
Title: THERAPEUTICALLY MODULATING APOB AND APOAI
Abstract:
MicroRNAs can be used to decrease expression of apolipoprotein B (apoB), increase expression of apolipoprotein A (apoA), and decrease expression of NCOR1. Use of these microRNAs can simultaneously reduce LDL and increase HDL in circulation and have applications in prevention and treatment of atherosclerosis, hyperlipidemia, and cardiovascular disease as well as other disorders associated with high apoB and/or low apoAI levels.