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1. (WO2017192924) CELL-BASED NEOANTIGEN VACCINES AND USES THEREOF

Pub. No.:    WO/2017/192924    International Application No.:    PCT/US2017/031171
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Fri May 05 01:59:59 CEST 2017
IPC: A61K 39/00
A61P 35/00
Applicants: FRED HUTCHINSON CANCER RESEARCH CENTER
Inventors: RIDDELL, Stanley, R.
VEATCH, Joshua
Title: CELL-BASED NEOANTIGEN VACCINES AND USES THEREOF
Abstract:
The present disclosure relates to immune cells that express an exogenous neoantigen and an immunogenicity enhancer, or to T cells that express an exogenous neoantigen, and their use in treating a disease or disorder, such as cancer for tumor associated neoantigens. Related expression constructs, kits, host cells, pharmaceutical compositions, and methods are also provided.