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1. (WO2017192858) OXAZOLINE PSEUDODIMERS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
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Pub. No.: WO/2017/192858 International Application No.: PCT/US2017/031071
Publication Date: 09.11.2017 International Filing Date: 04.05.2017
IPC:
C07D 413/06 (2006.01) ,C07D 263/28 (2006.01) ,A61K 31/421 (2006.01) ,A61P 25/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
28
Nitrogen atoms not forming part of a nitro radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
421
1,3-Oxazoles, e.g. pemoline, trimethadione
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
Applicants:
PURDUE PHARMA L.P. [US/US]; One Stamford Forum 201 Tresser Boulevard Stamford, Connecticut 06901, US
Inventors:
BLAKE, Paul; US
TAFESSE, Laykea; US
Agent:
COVERT, John M.; US
BANOWIT, Donald R.; US
BEZOS, Salvador M.; US
CALVO, Paul A.; US
CIMBALA, Michelle A.; US
COLLER III, Richard D.; US
CORNWELL, David K.S.; US
DESAI, Nirav N.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GILLENTINE, Marsha Rose; US
GOLDSTEIN, Jorge A.; US
GORDON, Lori A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross G.; US
HOLOUBEK, Michelle K.; US
HOOVER, Kenley K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MCGROARTY, John P.; US
MESSINGER, Michael V.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph E.; US
NANNENGA-COMBS, Bonnie; US
PICKARD, Byron L.; US
RAY, Michael B.; US
RYGIEL, Mark W.; US
SHEA, JR, Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
STRANG, Jonathan M.; US
TUMINARO, Jonathan; US
VARUGHESE, Dennies; US
WRIGHT, Jon E.; US
YONAN, Daniel E.; US
ZHOU, Lei; US
VIRA, Chandrika; US
CAMARCE, Christian; US
CONKLIN, Kyle; US
BODENSTEIN, Matthew; US
Priority Data:
62/331,71004.05.2016US
Title (EN) OXAZOLINE PSEUDODIMERS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
(FR) PSEUDODIMÈRES D'OXAZOLINE, COMPOSITIONS PHARMACEUTIQUES ET UTILISATION CORRESPONDANTES
Abstract:
(EN) The present disclosure is directed to oxazoline mono- and hetero-pseudodimer compounds, such as compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: These compounds are useful for treating pain. The present disclosure also relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of Formula (I) or (II) or a pharmaceutically acceptable salt or solvate thereof
(FR) La présente invention concerne des composés monopseudodimères et hétéropseudodimères d'oxazoline, tels que des composés de formule (I) ou des sels ou des solvates pharmaceutiquement acceptables correspondants. Ces composés sont utiles pour traiter la douleur. La présente invention concerne également des compositions pharmaceutiques comprenant un support pharmaceutiquement acceptable et une quantité thérapeutiquement efficace d'un composé de formule (I) ou (II) ou un sel ou un solvate pharmaceutiquement acceptable correspondant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)