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1. (WO2017192850) FLUOROPHORE-BASED KINASE SENSORS

Pub. No.:    WO/2017/192850    International Application No.:    PCT/US2017/031059
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Fri May 05 01:59:59 CEST 2017
IPC: C12Q 1/48
C07K 7/06
C07D 215/36
Applicants: ASSAYQUANT TECHNOLOGIES, INC.
Inventors: SCHAEFER, Erik, M.
IMPERIALI, Barbara
Title: FLUOROPHORE-BASED KINASE SENSORS
Abstract:
Disclosed are metal-binding analytical reagents that exhibit chelation-enhanced fluorescence (CHEF) upon binding to Mg2+. Also disclosed are methods of using the reagents for detecting the presence of or quantifying the activity of individual kinases or groups of kinases in a sample.