WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017192786) INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/192786 International Application No.: PCT/US2017/030933
Publication Date: 09.11.2017 International Filing Date: 03.05.2017
IPC:
A61K 35/17 (2015.01) ,A61K 35/15 (2015.01) ,A61P 37/02 (2006.01)
[IPC code unknown for A61K 35/17][IPC code unknown for A61K 35/15]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
Applicants: SQZ BIOTECHNOLOGIES COMPANY[US/US]; 134 Coolidge Avenue Watertown, MA 02472, US
Inventors: LOUGHHEAD, Scott; US
GILBERT, Jonathan, B.; US
BERNSTEIN, Howard; US
SHAREI, Armon, R.; US
MOORE, Finola; US
Agent: VANEVSKI, Filip; US
AHN, Sejin; US
ARJOMAND, Mehran; US
BANKO, Max; US
AIKEN, Charity; US
Priority Data:
62/331,38403.05.2016US
Title (EN) INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE
(FR) ADMINISTRATION INTRACELLULAIRE DE BIOMOLÉCULES POUR INDUIRE UNE TOLÉRANCE
Abstract:
(EN) The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell. In some embodiments, the tolerogenic and/or immunosuppressive immune cell is delivered to an individual and presentation of the antigen induces tolerance and/or suppresses an immune response to the antigen.
(FR) La présente invention concerne des procédés permettant d'induire une tolérance ou de supprimer une réponse immunitaire à un antigène en faisant passer une suspension cellulaire contenant une cellule immunitaire à travers un étranglement, l'étranglement déformant la cellule provoquant ainsi une perturbation de la cellule de telle sorte qu'un antigène et/ou un facteur tolérogénique pénètre dans la cellule, générant ainsi une cellule immunitaire tolérogénique et/ou immunosuppressive. Selon certains modes de réalisation, la cellule immunitaire tolérogénique et/ou immunosuppressive est administrée à un individu et la présentation d'un antigène induit une tolérance et/ou supprime une réponse immunitaire à l'antigène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)