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Pub. No.:    WO/2017/192620    International Application No.:    PCT/US2017/030688
Publication Date: 09.11.2017 International Filing Date: 02.05.2017
A61K 38/04 (2006.01), A61K 9/00 (2006.01), A61K 9/14 (2006.01), A61K 9/127 (2006.01), A61K 38/10 (2006.01), A61K 38/00 (2006.01)
Applicants: UNIVERSITY OF AUCKLAND [NZ/NZ]; Private Bag 92019 Auckland, 1142 (NZ).
OCUNEXUS THERAPEUTICS, INC. [US/US]; 12481 High Bluff Drive, Suite 150 San Diego, California 92130 (US)
Inventors: GREEN, Colin; (NZ).
KIM, Yeri; (NZ).
DUFT, Bradford; (US)
Agent: NORTON, Vicki G.; (US)
Priority Data:
62/331,416 03.05.2016 US
Abstract: front page image
(EN)Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions. Specifically, the disclosure provides peptides and peptide mimetics having pharmacokinetic and pharmacodynamic properties useful for modulating gap junction communication and hemichannel opening and other activities, wherein the peptides and peptide mimetics described herein are gap junction channel inhibitors. Further disclosed are sequences of the peptides and peptide mimetics.
(FR)L'invention concerne des composés et des compositions comprenant un canal de jonction lacunaire ou un bloqueur ou un inhibiteur d'hémicanal, ainsi que leurs procédés d'utilisation pour le traitement ou la prévention de maladies, de troubles et d'états vasculaires et autres.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)