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1. (WO2017192543) PIPERIDINES AS MENIN INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/192543 International Application No.: PCT/US2017/030577
Publication Date: 09.11.2017 International Filing Date: 02.05.2017
IPC:
C07D 401/04 (2006.01) ,C07D 401/14 (2006.01) ,C07D 405/04 (2006.01) ,C07D 211/34 (2006.01) ,A61K 31/4523 (2006.01) ,A61K 31/454 (2006.01) ,A61K 31/4545 (2006.01) ,A61P 35/00 (2006.01)
Applicants: REGENTS OF THE UNIVERSITY OF MICHIGAN[US/US]; Office of Technology Transfer 1600 Huron Parkway 2nd Floor Ann Arbor, MI 48109-2590, US
Inventors: WANG, Shaomeng; US
AGUILAR, Angelo; US
ZHANG, Ke; US
XU, Shilin; US
XU, Tianfeng; US
BERNARD, Denzil; US
HUANG, Liyue; US
Agent: NAPOLI, James J.; US
Priority Data:
62/330,35002.05.2016US
Title (EN) PIPERIDINES AS MENIN INHIBITORS
(FR) PIPÉRIDINES EN TANT QU'INHIBITEURS DE MÉNINE
Abstract: front page image
(EN) The present disclosure provides compounds represented by Formula (I): (Formula(I)) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R2, R3a, R3b, A, G, X, and Y are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.
(FR) La présente invention concerne des composés représentés par la formule (I): (formule (I)) et les sels, hydrates et solvates pharmaceutiquement acceptables de ceux-ci. Dans cette formule, R2, R3a, R3b, A, G, X, et Y sont tels que définis dans la description. La présente invention concerne également l'utilisation de composés de formule (I) pour le traitement d'une affection ou d'un trouble sensible à l’inhibition de la ménine tel que le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)