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1. (WO2017192485) HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR

Pub. No.:    WO/2017/192485    International Application No.:    PCT/US2017/030501
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Wed May 03 01:59:59 CEST 2017
IPC: C07D 401/14
C07D 403/04
C07D 405/14
C07D 403/14
C07D 405/04
C07D 409/14
C07D 471/04
A61K 31/4196
A61P 9/00
Applicants: AMGEN INC.
Inventors: CHEN, Xiaoqi
CHEN, Yinhong
CHENG, Alan C.
CONNORS, Richard V.
DEBENEDETTO, Mikkel V.
DRANSFIELD, Paul John
FU, Zice
HARVEY, James S.
HEATH, Julie Anne
HEDLEY, Simon J.
HOUZE, Jonathan
JUDD, Ted C.
KHAKOO, Aarif Yusuf
KOPECKY, David J.
LAI, Su-Jen
MA, Zhihua
NISHIMURA, Nobuko
OLSON, Steven H.
PATTAROPONG, Vatee
SWAMINATH, Gayathri
WANG, Xiaodong
YEH, Wen-Chen
Title: HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
Abstract:
Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.