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1. (WO2017191843) POLYMERIZED DRUG-CONTAINING PHARMACEUTICAL COMPOSITION
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Pub. No.: WO/2017/191843 International Application No.: PCT/JP2017/017288
Publication Date: 09.11.2017 International Filing Date: 02.05.2017
IPC:
A61K 31/351 (2006.01) ,A61K 31/555 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/12 (2006.01) ,A61K 47/18 (2017.01) ,A61K 47/24 (2006.01) ,A61K 47/26 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/42 (2017.01) ,A61K 47/50 (2017.01) ,A61K 9/08 (2006.01) ,A61K 9/14 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
351
not condensed with another ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
555
containing heavy metals, e.g. hemin, hematin, melarsoprol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
[IPC code unknown for A61K 47/50]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
一般財団法人バイオダイナミックス研究所 BIODYNAMIC RESEARCH FOUNDATION [JP/JP]; 熊本県熊本市東区湖東3丁目21番24号 21-24, Kotoh 3-chome, Higashi-ku, Kumamoto-shi, Kumamoto 8620909, JP
Inventors:
前田 浩 MAEDA, Hiroshi; JP
方 軍 FANG, Jun; JP
Agent:
鮫島 睦 SAMEJIMA, Mutsumi; JP
落合 康 OCHIAI, Ko; JP
Priority Data:
2016-09340706.05.2016JP
Title (EN) POLYMERIZED DRUG-CONTAINING PHARMACEUTICAL COMPOSITION
(FR) COMPOSITION PHARMACEUTIQUE CONTENANT UN MÉDICAMENT POLYMÉRISÉ
(JA) 高分子化薬物含有医薬組成物
Abstract:
(EN) The present invention provides a formulation having excellent solubility and/or stability of a polymerized drug, and more specifically, a pharmaceutical composition including a polymerized drug, a dissolution promoter and/or stabilizer, and an aqueous solvent, wherein the dissolution promoter and/or stabilizer is at least one selected from the group consisting of (1) proteins, (2) synthetic polymers, (3) sugars or sugar alcohols, (4) inorganic salts, (5) amino acids, (6) phospholipids, (7) aliphatic alcohols, (8) medium-chain fatty acids, and (9) mucopolysaccharides.
(FR) La présente invention concerne une formulation présentant une excellente solubilité et/ou stabilité d'un médicament polymérisé, et plus précisément, une composition pharmaceutique comprenant un médicament polymérisé, un promoteur de dissolution et/ou un stabilisant, et un solvant aqueux, le promoteur de dissolution et/ou le stabilisant étant au moins un élément choisi dans le groupe constitué par (1) les protéines, (2) les polymères synthétiques, (3) les sucres ou les alcools de sucre, (4) les sels minéraux, (5) les acides aminés, (6) les phospholipides, (7) les alcools aliphatiques, (8) les acides gras à chaîne moyenne et (9) les mucopolysaccharides.
(JA) 本発明は、高分子化薬物の溶解性および/または安定性に優れた製剤、より具体的には、高分子化薬物と、溶解促進および/または安定化剤と、水系溶媒を含む、医薬組成物であって、該溶解促進および/または安定化剤が、(1)タンパク質、(2)合成ポリマー、(3)糖または糖アルコール、(4)無機塩類、(5)アミノ酸、(6)リン脂質、(7)脂肪族アルコール、(8)中鎖脂肪酸、および(9)ムコ多糖からなる群から選択される少なくとも1種である医薬組成物を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)