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1. WO2017191691 - GROWTH INDUCTION SYSTEM, GROWTH INDUCTION CONTROL APPARATUS, GROWTH INDUCTION CONTROL METHOD, AND GROWTH INDUCTION CONTROL PROGRAM

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Publication Number WO/2017/191691
Publication Date 09.11.2017
International Application No. PCT/JP2016/067599
International Filing Date 13.06.2016
IPC
C12M 3/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
C12N 5/071 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
CPC
B01L 2300/087
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
087Multiple sequential chambers
B01L 2400/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
04Moving fluids with specific forces or mechanical means
B01L 3/502715
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502715characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
B01L 3/50273
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
50273characterised by the means or forces applied to move the fluids
C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
1Apparatus for enzymology or microbiology
C12M 29/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
29Means for introduction, extraction or recirculation of materials, e.g. pumps
26Conditioning fluids entering or exiting the reaction vessel
Applicants
  • インテグリカルチャー株式会社 INTEGRICULTURE INC. [JP]/[JP]
Inventors
  • 羽生　雄毅 HANYU Yuki
  • 川島　一公 KAWASHIMA Ikko
Agents
  • 諌山　太郎 ISAYAMA Taro
Priority Data
2016-09283602.05.2016JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) GROWTH INDUCTION SYSTEM, GROWTH INDUCTION CONTROL APPARATUS, GROWTH INDUCTION CONTROL METHOD, AND GROWTH INDUCTION CONTROL PROGRAM
(FR) SYSTÈME D’INDUCTION DE CROISSANCE, APPAREIL DE CONTRÔLE DE L’INDUCTION DE CROISSANCE, PROCÉDÉ DE CONTRÔLE DE L’INDUCTION DE CROISSANCE, ET PROGRAMME DE CONTRÔLE DE L’INDUCTION DE CROISSANCE
(JA) 成長誘導システム、成長誘導制御装置、成長誘導制御方法、および、成長誘導制御プログラム
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Abstract
(EN) In order to suppress the cost of adding a cytokine for each growth stage and induce growth, the growth induction system according to the present invention is provided with: a first culture tank for perfusing an organism-derived growth induction object with a culture medium; a second culture tank for perfusing a cytokine-secreting secretion body with the culture medium; and a growth induction control apparatus provided with a detection unit, a storage unit, and a control unit; wherein a growth induction protocol for prescribing a growth induction procedure is stored, and in the control unit, a growth condition of the growth induction object is detected via the detection unit, and the flow rate at which a culture medium including the cytokine secreted by the secretion body is supplied to the growth induction object is controlled in response to the growth condition of the growth induction object on the basis of the growth induction protocol.
(FR) Afin de supprimer le coût d’addition d’une cytokine pour chaque stade de croissance et d'induire la croissance, le système d’induction de croissance selon la présente invention est muni : d'une première cuve de culture permettant la perfusion d’un objet d’induction de croissance dérivé d’un organisme avec un milieu de culture ; d'une seconde cuve de culture pour la perfusion d’un corps de sécrétion sécrétant une cytokine avec le milieu de culture ; et d'un appareil de contrôle de l’induction de croissance prévu avec une unité de détection, une unité de stockage, et une unité de commande ; où un protocole d’induction de croissance pour prescrire une procédure d’induction de croissance est stocké, et dans l’unité de commande, un état de croissance de l’objet d’induction de croissance est détecté par l'intermédiaire de l’unité de détection, et le débit auquel un milieu de culture comprenant la cytokine sécrétée par le corps de sécrétion est alimenté à l’objet d’induction de croissance est contrôlé en réponse aux conditions de croissance de l’objet d’induction de croissance sur la base du protocole d’induction de croissance.
(JA) 成長段階ごとにサイトカインを添加するコストを抑えて成長を誘導するため、生体由来の成長誘導対象に培養液を灌流する第一の培養槽、サイトカインを分泌する分泌体に培養液を灌流する第二の培養槽、および、検出部と記憶部と制御部とを備えた成長誘導制御装置、を備えた成長誘導システムにおいて、成長誘導手順を規定する成長誘導プロトコルを記憶させ、制御部において、検出部を介して成長誘導対象の成長状況を検出し、成長誘導プロトコルに基づいて、成長誘導対象の成長状況に応じて、分泌体が分泌したサイトカインを含む培養液を成長誘導対象に供給する流量を制御する。
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