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1. (WO2017191579) AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/191579    International Application No.:    PCT/IB2017/052577
Publication Date: 09.11.2017 International Filing Date: 03.05.2017
IPC:
C07K 7/64 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel (CH)
Inventors: BURGER, Matthew T.; (US).
JIN, Yunho; (US).
UNO, Tetsuo; (US)
Agent: NOVARTIS AG; Lichtstrasse 35 4056 Basel (CH)
Priority Data:
62/332,117 05.05.2016 US
Title (EN) AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
(FR) DÉRIVÉS D'AMATOXINE ET LEURS CONJUGUÉS À UTILISER EN TANT QU'INHIBITEURS DE L'ARN POLYMÉRASE
Abstract: front page image
(EN)The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates.
(FR)La présente invention concerne des peptides cycliques cytotoxique de formule (A), des méthodes pour inhiber l'ARN polymérase à l'aide desdits peptides cycliques, des immunoconjugués comprenant lesdits peptides cycliques (c'est à dire des conjugués anticorps-médicament), des compositions pharmaceutiques comprenant lesdits immunoconjugués à base de peptides cycliques, des compositions comprenant lesdits immunoconjugués à base de peptides cycliques avec un co-agent thérapeutique et des méthodes de traitement faisant intervenir lesdits immunoconjugués à base de peptides cycliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)