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1. (WO2017191195) UNSATURATED AMINO ACIDS

Pub. No.:    WO/2017/191195    International Application No.:    PCT/EP2017/060552
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Thu May 04 01:59:59 CEST 2017
IPC: C12P 13/04
C12P 13/12
C07C 323/58
C07C 319/02
C12N 9/08
C12N 9/02
C07K 14/21
C12N 15/52
C12N 1/21
Applicants: EVONIK DEGUSSA GMBH
Inventors: HAAS, Thomas
HECKER, Anja
BÜLTER, Thomas
KROUTIL, Wolfgang
FABER, Kurt
Title: UNSATURATED AMINO ACIDS
Abstract:
There is provided a method of producing at least one unsaturated amino acid from at least one amino acid comprising at least two carbonyl groups, the method comprising (a) contacting a recombinant microbial cell with a medium comprising the amino acid comprising the carbonyl groups, wherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E) selected from the CYP152 10 peroxygenase family, and -at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein.