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1. (WO2017191187) NUCLEOLAR STRUCTURE EVALUATION AND MANIPULATION

Pub. No.:    WO/2017/191187    International Application No.:    PCT/EP2017/060532
Publication Date: Fri Nov 10 00:59:59 CET 2017 International Filing Date: Thu May 04 01:59:59 CEST 2017
IPC: G06T 7/00
G01N 33/50
Applicants: UNIVERSITÉ LIBRE DE BRUXELLES
Inventors: LAFONTAINE, Denis
DE VLEESCHOUWER, Christophe
NICOLAS, Emilien
PARISOT, Pascaline
Title: NUCLEOLAR STRUCTURE EVALUATION AND MANIPULATION
Abstract:
The nucleolus is a potent disease biomarker and a target in for instance cancer therapy. The present invention relates to how depletion of each of the eighty human r-proteins affects nucleolar structure, pre-rRNA processing, mature rRNA accumulation and p53 steady-state level. The present invention further relates to an image -processing program for qualitative and quantitative discrimination of normal from altered nucleolar morphology.