WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2017191073) MUTATIONAL SIGNATURES IN CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/191073    International Application No.:    PCT/EP2017/060289
Publication Date: 09.11.2017 International Filing Date: 28.04.2017
IPC:
C12Q 1/68 (2006.01), G06F 19/24 (2011.01)
Applicants: GENOME RESEARCH LIMITED [GB/GB]; Wellcome Trust Genome Campus Hinxton Cambridge Cambridgeshire CB10 1SA (GB)
Inventors: NIK-ZAINAL, Serena; (GB).
STRATTON, Mike; (GB).
DAVIES, Helen; (GB).
GLODZIK, Dominik; (GB)
Agent: HODSDON, Stephen; (GB).
ADDISS, John; (GB).
ANDREWS, Robert; (GB).
BAILEY, Sam; (GB).
BRASNETT, Adrian; (GB).
BREARLEY, Sarah; (GB).
CARLISLE, Julie; (GB).
CARTER, Stephen; (GB).
CASLEY, Christopher; (GB).
CLEGG, Richard; (GB).
CRIPPS, Joanna; (GB).
DALE, Elizabeth; (GB).
DENISON, Christopher; (GB).
DUNNE, Paul; (GB).
FORREST, Graham; (GB).
GILL, Stephen; (GB).
GRAHAM, Emma; (GB).
GREEN, Katherine; (GB).
GREGORY, Adam; (GB).
HARRISON, Susan; (GB).
HAYES, Emily; (GB).
JOHNSON, Richard; (GB).
JONES, Rachel; (GB).
KEIRSTEAD, Tanis; (GB).
KIDDLE, Simon; (GB).
KREMER, Simon; (GB).
LEACH, James; (GB).
LENTHALL, Joseph; (GB).
LYONS, June; (GB).
MCGUINN, Callum; (GB).
MOORE, Graeme; (GB).
NAYLOR, Matthew; (GB).
OXLEY, Rachel; (GB).
PARRY, Simon; (GB).
SALISBURY, Frances; (GB).
SMITH, Matthew; (GB).
STONER, Patrick; (GB).
SUTCLIFFE, Nicholas; (GB).
TOLLERVEY, Rebecca; (GB).
WALTON, Seán; (GB).
WARD, Eliot; (GB).
WATSON, Robert; (GB).
WEBSTER, Jeremy; (GB).
WESCOTT, Rhiannon; (GB).
WILLS, Jonathan; (GB).
WOOLLEY, Lindsey; (GB).
WYTENBURG, Wilhelmus; (GB)
Priority Data:
1607629.1 01.05.2016 GB
Title (EN) MUTATIONAL SIGNATURES IN CANCER
(FR) SIGNATURES MUTATIONNELLES DANS LE CANCER
Abstract: front page image
(EN)The present invention relates to the identification of a number of mutational signatures in patients with cancer. The mutational signatures include new base substitution signatures and rearrangement signatures. The signatures were identified by whole genome sequencing of 560 breast cancers and the application of new and existing mathematical methods to the base substitution and rearrangements found in those cancers.
(FR)La présente invention concerne l'identification d'un certain nombre de signatures mutationnelles chez des patients atteints d'un cancer. Les signatures mutationnelles comprennent des nouvelles signatures de substitution et de signatures de réarrangement de bases. Les signatures ont été identifiées par le séquençage du génome entier de 560 cancers du sein et l'application de méthodes mathématiques nouvelles et existantes à la substitution et au réarrangement de bases observés dans ces cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)