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1. (WO2017190115) SUSTAINED RELEASE FORMULATION AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/190115 International Application No.: PCT/US2017/030312
Publication Date: 02.11.2017 International Filing Date: 29.04.2017
IPC:
A61K 9/06 (2006.01) ,C08G 63/664 (2006.01)
Applicants: I-NOVION, INC.[US/US]; 6 Dawn Lane Randolph, New Jersey 07869, US
Inventors: VELAGALETI, Poonam R.; US
GILGER, Brian C.; US
GRAU, Ulrich; DE
AMIN, Rasidul; US
ABBARAJU, Santhi; US
Agent: DYKEMAN, David J.; US
XIE, Fang; US
Priority Data:
62/330,02029.04.2016US
Title (EN) SUSTAINED RELEASE FORMULATION AND USE THEREOF
(FR) FORMULATION À LIBÉRATION PROLONGÉE ET SON UTILISATION
Abstract: front page image
(EN) Provided herein are extended release polymers. In one aspect, a composition for sustained release of active ingredients comprises a block polymer having formula: PEG-PCL-PLA-PCL-PEG or PGA-PCL-PEG-PCL-PGA. The extended release block polymers modulate drug release rate based on the hydrophobicity of the PTSgel polymer irrespective of the nature of drug. PTSgel polymers are biodegradable, thermosensitive, and compatible with hydrophilic, hydrophobic, and combinations thereof, biologic or chemical active agents.
(FR) L'invention concerne des polymères à libération prolongée. Selon un aspect, une composition permettant une libération prolongée de principes actifs comprend un polymère séquencé de formule : PEG-PCL-PLA-PCL-PEG ou PGA-PCL-PEG-PCL-PGA. Les polymères séquencés à libération prolongée modulent la vitesse de libération du médicament sur la base de l'hydrophobicité du polymère de type PTSgel, indépendamment de la nature du médicament. Les polymères de type PTSgel sont biodégradables, thermosensibles et compatibles avec des agents actifs biologiques ou chimiques, hydrophiles, hydrophobes et des combinaisons de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)