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1. (WO2017190086) DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/190086    International Application No.:    PCT/US2017/030261
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
C07D 401/14 (2006.01), C07D 401/04 (2006.01), C07D 231/12 (2006.01), C07D 305/08 (2006.01), C07D 307/22 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61P 3/00 (2006.01), A61P 9/00 (2006.01), A61P 35/00 (2006.01)
Applicants: FGH BIOTECH, INC. [US/US]; 414 Thamer Circle Houston, Texas 77024-6918 (US)
Inventors: HUFF, Joel; (US).
UESUGI, Motonari; (JP).
KINCAID, John; (US)
Agent: RICE, Janice V.; (US).
ANDERTON JR., H. Thomas; (US).
GUSLER, Gloria; (US).
KERRIGAN, Cameron; (US).
LAI, Karen; (US).
LIU, Qun; (US).
LUPKOWSKI, Mark; (US).
MORALES, Norman; (US).
NOSON, Kevin; (US).
OSTOMEL, Todd; (US).
PATHAK, Rahul; (US).
REED, James L.; (US)
Priority Data:
62/330,049 29.04.2016 US
Title (EN) DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES
(FR) COMPOSÉS DE PYRAZOLE DI-SUBSTITUÉS POUR LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN)Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).
(FR)L'invention concerne des composés, des compositions pharmaceutiques comprenant les composés, et des procédés d'utilisation des composés et des compositions dans le traitement d'un état de santé, d'une maladie ou d'un trouble associé à une activation anormale de la voie de SREBP, y compris des troubles métaboliques tels que l'obésité, le cancer, les maladies cardiovasculaires et la stéatose hépatique non alcoolique (SHNA), le composé étant conforme à la formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)