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1. (WO2017190059) STABILIZING PROINSULIN MONOMERS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/190059    International Application No.:    PCT/US2017/030214
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
C07D 491/147 (2006.01), A61P 3/10 (2006.01), C07K 14/62 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; 1600 Huron Parkway, 2nd Floor Ann Arbor, Michigan 448109 (US)
Inventors: ARVAN, Peter; (US).
LIU, Ming; (US)
Agent: STAPLE, David W.; (US)
Priority Data:
62/328,910 28.04.2016 US
Title (EN) STABILIZING PROINSULIN MONOMERS
(FR) STABILISATION DE MONOMÈRES DE LA PROINSULINE
Abstract: front page image
(EN)Provided herein are compositions and methods for the protection of the proinsulin dimerization surface, and the treatment of poor insulin production, pancreatic beta cell failure, and diabetes therewith. In particular, misfolded proinsulin is prevented from propagating its deleterious effects by inhibiting the dimerization of proinsulin in general and misfolded proinsulin specifically.
(FR)L'invention concerne des compositions et des procédés pour la protection de la surface de dimérisation de la proinsuline, et le traitement de la mauvaise production d'insuline, du déficit de cellules bêta pancréatiques et du diabète. En particulier, la propagation des effets délétères de la pro-insuline mal pliée est empêchée par l'inhibition de la dimérisation de la proinsuline en général et de la proinsuline mal pliée en particulier.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)