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1. (WO2017190050) INHIBITORS OF SOLUBLE ADENYLYL CYCLASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/190050    International Application No.:    PCT/US2017/030188
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
A61K 31/506 (2006.01), C07D 239/48 (2006.01)
Applicants: CORNELL UNIVERSITY [US/US]; Cornell Center For Technology Licensing (''CTL'') At Cornell University 395 Pine Tree Road, Suite 310 Ithaca, NY 14850 (US).
UNIVERSITY OF BAYREUTH [DE/DE]; Stabsabteilung Entrepreneurship Und Innovation Universitatsstrabe 30 95447 Bayreuth (DE)
Inventors: BUCK, Jochen; (US).
LEVIN, Lonny; (US).
RAMOS-ESPIRITU, Lavoisier; (US).
STEEGBORN, Clemens; (DE)
Agent: WATT, Rachel, S.; (US).
KADLE, Ranjana; (US).
ROMAN, Paul, J.; (US).
CUTAIA, Alfonzo, I; (US).
LUCEK, Nathaniel, W.; (US)
Priority Data:
62/328,806 28.04.2016 US
Title (EN) INHIBITORS OF SOLUBLE ADENYLYL CYCLASE
(FR) INHIBITEURS DE L'ADÉNYLCYCLASE SOLUBLE
Abstract: front page image
(EN)Provided are 6-amino substituted 2,6-diamino-4-choropyrimidine compounds which are specific inhibitors of soluble adenylyl cyclase. The compounds can be formulated with pharmaceutical carriers and used for reducing cyclic AMP levels. The compositions can be used for treatment of various considitions including ocular hypotony.
(FR)L'invention concerne des composés 2,6-diamino-4-chloropyrimidine substitués par un groupe amino en position 6 qui sont des inhibiteurs spécifiques de l'adénylcyclase soluble. Les composés peuvent être formulés avec des excipients pharmaceutiques et utilisés pour réduire les taux d'AMP cyclique. Les compositions peuvent être utilisées pour le traitement de divers états pathologiques, y compris d'une hypotonie oculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)