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Pub. No.:    WO/2017/190032    International Application No.:    PCT/US2017/030164
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
A61K 38/04 (2006.01), A61K 38/10 (2006.01), A61K 38/17 (2006.01), C07K 7/00 (2006.01), C07K 7/02 (2006.01), C07K 7/04 (2006.01), C07K 7/06 (2006.01)
Applicants: NATIONAL UNIVERSITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road Singapore 119077 (SG).
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; Harvard Medical School 75 Francis Street Boston, MA 02115 (US).
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #9-10 Connexis North Tower Singapore 138632 (SG)
Inventors: LIU, Bee, Hui; (SG).
TENEN, Daniel, Geoffrey; (SG).
CHAI, Li; (US).
CHIA, Cheng San, Brian; (SG).
POULSEN, Anders; (SG)
Agent: CARROLL, Alice, O.; (US).
SMITH, James, M.; (US).
PIERCE, N., Scott; (US).
WAKIMURA, Mary, Lou; (US).
BROOK, David, E.; (US)
Priority Data:
62/329,010 28.04.2016 US
Abstract: front page image
(EN)The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation of SALL4 are also provided.
(FR)La présente invention concerne, dans certains modes de réalisation, des peptides isolés et des compositions pharmaceutiques comprenant des peptides isolés qui se lient à la protéine de liaison du rétinoblastome 4 RBBp4 de telle sorte que, la liaison bloque l'interaction SALL4-RBBp4. L'invention porte également sur des méthodes d'inhibition de la liaison de SALL4 avec RBBp4 et sur des méthodes de traitement d'un sujet ayant un trouble médié par une dérégulation de SALL4.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)