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1. (WO2017190018) SEQUENCING METHOD EMPLOYING TERNARY COMPLEX DESTABILIZATION TO IDENTIFY COGNATE NUCLEOTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/190018    International Application No.:    PCT/US2017/030143
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
C12Q 1/68 (2006.01)
Applicants: OMNIOME, INC. [US/US]; 10575 Roselle Street San Diego, California 92121 (US)
Inventors: IYIDOGAN, Pinar; (US).
VIJAYAN, Kandaswamy; (US)
Agent: THOMAS, Tiffany B.; (US)
Priority Data:
62/329,933 29.04.2016 US
62/487,586 20.04.2017 US
Title (EN) SEQUENCING METHOD EMPLOYING TERNARY COMPLEX DESTABILIZATION TO IDENTIFY COGNATE NUCLEOTIDES
(FR) PROCÉDÉ DE SÉQUENÇAGE FAISANT APPEL À LA DÉSTABILISATION D'UN COMPLEXE TERNAIRE POUR IDENTIFIER DES NUCLÉOTIDES APPARENTÉS
Abstract: front page image
(EN)Provided are methods and systems for detecting formation of nucleotide-specific ternary complexes comprising a DNA polymerase, a nucleic acid, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide without requiring chemical incorporation of the nucleotide into the primer. These results can even be achieved in procedures employing unlabeled, native nucleotides.
(FR)L'invention concerne des procédés et des systèmes permettant de détecter la formation de complexes ternaires spécifiques de nucléotides comprenant une ADN polymérase, un acide nucléique, et un nucléotide complémentaire de la base matrice de l'acide nucléique matrice présent dans l'armorce. Ces procédés et systèmes facilitent la détermination du nucléotide correct suivant sans exiger l'incorporation chimique du nucléotide dans l'amorce. Ces résultats peuvent même être obtenus dans des procédures utilisant des nucléotides natifs non marqués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)