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1. (WO2017190016) CYCLOPHILIN 40 FOR REDUCTION OF NEUROTOXIC FIBRILS AND TREATMENT OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/190016    International Application No.:    PCT/US2017/030140
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
A61K 38/17 (2006.01), A61K 31/445 (2006.01), A61K 31/55 (2006.01), A61K 31/27 (2006.01)
Applicants: UNIVERSITY OF SOUTH FLORIDA [US/US]; 3802 Spectrum Blvd., Suite 100 Tampa, FL 33612-9220 (US).
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; 810 Vermont Avenue N.W. Washington, DC 20420 (US)
Inventors: DICKEY, Chad; .
BAKER, Jeremy, Dustin; (US)
Agent: LADWIG, Glenn, P.; (US).
LLOYD, Jeff; (US).
EISENSCHENK, Frank, C.; (US).
PACE, Doran, R.; (US).
SALIWANCHIK, David, R.; (US)
Priority Data:
62/329,317 29.04.2016 US
Title (EN) CYCLOPHILIN 40 FOR REDUCTION OF NEUROTOXIC FIBRILS AND TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) CYCLOPHILINE 40 UTILISÉE DANS LA RÉDUCTION DES FIBRILLES NEUROTOXIQUES ET DANS LE TRAITEMENT DES MALADIES NEURODÉGÉNÉRATIVES
Abstract: front page image
(EN)The present invention concerns the use of peptidyl-prolyl isomerase cyclophilin 40 (CyP40) for reduction of neurotoxic fibrils and treatment and prevention of neurodegenerative diseases associated with amyloid fibril aggregation. Aspects of the invention include compositions, methods, dosage forms, and kits for treating or preventing a neurodegenerative disease or condition associated with amyloid fibril aggregation in a human or animal subject, and for disaggregating neurofibrillary aggregates in vitro or in vivo, using CyP40, or a biologically active fragment thereof.
(FR)L'invention concerne l'utilisation de peptidylprolyl isomérase cyclophiline 40 (CyP40) dans la réduction des fibrilles neurotoxiques et dans le traitement et la prévention de maladies neurodégénératives liées à l'agrégation des fibrilles amyloïdes. Des aspects de l'invention concernent des compositions, des méthodes, des formes dosifiées et des kits servant à traiter ou à prévenir une maladie ou une affection neurodégénérative liée à l'agrégation de fibrilles amyloïdes chez un individu humain ou animal, et à désagréger des agrégats neurofibrillaires in vitro or in vivo au moyen de CyP40 ou d'un fragment biologiquement actif de celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)