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1. (WO2017189925) METHODS OF PREPARING PEPTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/189925 International Application No.: PCT/US2017/029969
Publication Date: 02.11.2017 International Filing Date: 27.04.2017
IPC:
C07K 1/06 (2006.01) ,C07K 1/107 (2006.01) ,C07K 14/47 (2006.01) ,A61K 38/16 (2006.01) ,A61K 38/26 (2006.01)
Applicants: C S BIO CO.[US/US]; 20 Kelly Court Menlo Park, CA 94025, US
Inventors: WANG, Wei; US
CHANG, Jason; US
SLAVAZZA, Dario; US
CHANG, Heng, Wei; US
Agent: QI, Yan; US
BASOL, Erol, C.; US
BANKO, Max; US
AHN, Sejin; US
ARJOMAND, Mehran; US
Priority Data:
62/329,09728.04.2016US
Title (EN) METHODS OF PREPARING PEPTIDES
(FR) PROCÉDÉS DE PRÉPARATION DE PEPTIDES
Abstract: front page image
(EN) The present invention provides methods of preparing a peptide having an N-terminal histidine, and compositions comprising a plurality of peptides prepared by the methods. The methods disclosed herein reduce racemization of the N-terminal histidine in the peptides during the synthesis process, thereby improving the yield and purity of the peptide compositions. Exemplary peptides that can be manufactured with the methods include Exenatide, Lixisenatide, and Liraglutide.
(FR) La présente invention concerne des procédés de préparation d'un peptide ayant une histidine N-terminale, et des compositions comprenant une pluralité de peptides préparés au moyen des procédés. Les procédés décrits dans l'invention réduisent la racémisation de l'histidine N-terminale dans les peptides pendant le processus de synthèse, ce qui améliore ainsi le rendement et la pureté des compositions peptidiques. Des exemples de peptides qui peuvent être fabriqués avec les procédés comprennent l'exénatide, le lixisenatide et le liraglutide.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)