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1. (WO2017189893) 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES ARE INHIBITORS OF RAC/CDC42 GTPASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/189893    International Application No.:    PCT/US2017/029921
Publication Date: 02.11.2017 International Filing Date: 27.04.2017
IPC:
A61K 31/4192 (2006.01), A61K 31/404 (2006.01), C07D 249/00 (2006.01), C07D 405/04 (2006.01), G01N 33/574 (2006.01)
Applicants: UNIVERSITY OF PUERTO RICO [US/US]; Carretera #1, Esquina Carrertera #8838, Sector El Cinco San Juan, 00926 (PR)
Inventors: VLAAR, Cornelus P.; (PR).
DHARMAWARDHANE FLANAGAN, Surangani; (PR).
HERNANDEZ-O'FARRILL, Eliud; (PR).
CASTILLO-PICHARDO, Linette; (PR)
Agent: MARTIN, Alice O.; (US)
Priority Data:
62/328,282 27.04.2016 US
Title (EN) 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES ARE INHIBITORS OF RAC/CDC42 GTPASES
(FR) 1, 2, 3-TRIAZOLES 1,5-DISUBSTITUÉS QUI SONT DES INHIBITEURS DES GTPASES RAC/CDC42
Abstract: front page image
(EN)Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.
(FR)L'invention concerne des composés qui inhibent les RhoGTPases qui sont utiles pour inhiber des maladies hyperprofitives et néoplasiques. Plus particulièrement, les composés inhibent les GTPases Rac et Cdc42 qui sont suractives ou surexprimées dans des voies de signalisation dans le cancer et la métastase. L'invention concerne également des méthodes de traitement du cancer et de maladies hyperprolifératives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)