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1. (WO2017189866) POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/189866 International Application No.: PCT/US2017/029879
Publication Date: 02.11.2017 International Filing Date: 27.04.2017
IPC:
C07K 7/62 (2006.01) ,A61K 38/12 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50
Cyclic peptides containing at least one abnormal peptide link
54
with at least one abnormal peptide link in the ring
60
the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
62
Polymyxins; Related peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants: SPERO OPCO[US/US]; 675 Massachusetts Avenue 14th Floor Cambridge, Massachusetts 02139, US
Inventors: LISTER, Troy; US
SHARMA, Rajiv; US
ZABAWA, Thomas; US
ZAHLER, Robert; US
Agent: MAXWELL, Leslie-Anne; US
Priority Data:
62/328,14627.04.2016US
Title (EN) POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS
(FR) ANALOGUES DE LA POLYMYXINE UTILES EN TANT QUE POTENTIALISATEURS D'ANTIBIOTIQUE
Abstract:
(EN) The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).
(FR) L'invention concerne des composés représentés par la formule (I) ou un tautomère de ceux-ci, ou un sel pharmaceutiquement acceptable de l'un ou l'autre des composés mentionnés. Les variables A, R1 et R2 sont définies dans la description. L'invention concerne en outre des compositions pharmaceutiques comprenant un composé représenté par la formule I, conjointement avec au moins un excipient pharmaceutiquement acceptable. L'invention concerne également un procédé de sensibilisation de bactéries à un agent antibactérien, qui consiste à administrer à un patient infecté par les bactéries, simultanément ou séquentiellement, une quantité thérapeutiquement efficace de l'agent antibactérien et un composé représenté par la formule (I).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)