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1. (WO2017189856) COMPOSITIONS AND METHODS FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/189856 International Application No.: PCT/US2017/029859
Publication Date: 02.11.2017 International Filing Date: 27.04.2017
IPC:
A61K 31/519 (2006.01) ,A61K 31/18 (2006.01) ,A61K 31/706 (2006.01) ,A61K 35/02 (2015.01) ,A61K 35/04 (2006.01) ,G01N 33/574 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
02
from inanimate materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
02
from inanimate materials
04
Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate, e.g. Ichthyol
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION[US/US]; 722 Preston Avenue, Suite 107 Charlottesville, VA 22903, US
Inventors: ABBAS, Tarek; US
Agent: TAYLOR, Arles, A., JR.; US
Priority Data:
62/328,18327.04.2016US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING CANCER
(FR) COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) Provided are compositions for inhibiting cellular proliferation comprising one or more CRL4CDT2 ubiquitin ligase inhibitors. Also provided are uses of the disclosed compositions to prepare medicaments, for treating and/or preventing diseases, disorders, and conditions, particularly for treating cancer, inducing apoptosis and/or rereplication in cells, inhibiting undesirable neddylation, overcoming vemurafenib-resistance in cells, treating melanoma, breast cancer, head and neck squamous carcinoma cell (HNSCC) cancer, a solid tumor, hepatocellular carcinoma, colorectal cancer, a non-small-cell lung cancer, serous ovarian cancer, papillary thyroid carcinoma, or ameloblastoma, and pharmaceutical compositions comprising the same.
(FR) L'invention porte sur des compositions visant à inhiber la prolifération cellulaire et comprenant un ou plusieurs inhibiteurs de l'ubiquitine ligase CRL4 CDT2. L'invention concerne également des utilisations des compositions décrites pour préparer des médicaments, pour traiter et/ou prévenir des maladies, des troubles et des affections, en particulier pour traiter le cancer, induire l'apoptose et/ou la re-réplication dans les cellules, inhiber toute neddylation indésirable, surmonter la résistance au vémurafénib dans les cellules, traiter le mélanome, le cancer du sein, le carcinome à cellules squameuses de la tête et du cou (HNSCC), une tumeur solide, un carcinome hépatocellulaire, un cancer colorectal, un cancer du poumon non à petites cellules, un cancer de l'ovaire séreux, un carcinome papillaire de la thyroïde ou un améloblastome, ainsi que des compositions pharmaceutiques en comprenant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)