WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2017189753) ISL1-BASED GENE THERAPY TO TREAT HEARING LOSS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/189753    International Application No.:    PCT/US2017/029682
Publication Date: 02.11.2017 International Filing Date: 26.04.2017
IPC:
A61K 9/00 (2006.01), A61K 38/17 (2006.01), A61K 45/06 (2006.01), C12Q 1/68 (2006.01), G01N 33/50 (2006.01)
Applicants: MASSACHUSETTS EYE AND EAR INFIRMARY [US/US]; 325 Charles Street, 6th Floor Boston, MA 02114 (US)
Inventors: CHEN, Zheng-yi; (US).
JU, Yujuan; (US)
Agent: ZELNER, David, J.; (US).
ZACHARIADES, Nicholas, A.; (US)
Priority Data:
62/327,639 26.04.2016 US
Title (EN) ISL1-BASED GENE THERAPY TO TREAT HEARING LOSS
(FR) THÉRAPIE GÉNIQUE À BASE D'ISL1 DESTINÉE À TRAITER UNE PERTE AUDITIVE
Abstract: front page image
(EN)Compositions for the prevention, treatment and/or reversal of hearing loss include vectors encoding an Islet- 1 (Isl1) nucleic acid sequence. The over-expression of Isl 1 molecules in ear cells, for example, hair cells, results in the treatment of hearing loss due to age, noise exposure or any idiopathic causes.
(FR)La présente invention concerne des compositions destinées à la prévention, au traitement et/ou à l'inversion de la perte auditive comprenant des vecteurs codant pour une séquence d'acide nucléique d'îlot-1 (Isl1). La surexpression de molécules Isl 1 dans des cellules auditives, par exemple les cellules ciliées, entraîne le traitement de la perte auditive due à l'âge, à l'exposition au bruit ou à toute cause idiopathique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)