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1. (WO2017189730) TREATMENT OF HIPPO PATHWAY MUTANT TUMORS AND METHODS OF IDENTIFYING SUBJECTS AS CANDIDATES FOR TREATMENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/189730    International Application No.:    PCT/US2017/029646
Publication Date: 02.11.2017 International Filing Date: 26.04.2017
IPC:
C07K 14/705 (2006.01), C07K 16/24 (2006.01), C07K 16/30 (2006.01), A61B 10/02 (2006.01), A61K 31/33 (2006.01), A61K 31/495 (2006.01), A61K 31/505 (2006.01), A61K 31/506 (2006.01)
Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; One Gustave L. Levy Place New York, NY 10029 (US)
Inventors: AARONSON, Stuart, A.; (US).
TROILO, Albino; (US).
BENSON, Erica, K.; (US)
Agent: TISCHNER, Tate, L.; (US).
CHILDS, Carissa, R.; (US).
GOLDMAN, Michael, L.; (US).
O'GARA, Megan, Thisse; (US).
MERKEL, Edwin, V.; (US)
Priority Data:
62/327,903 26.04.2016 US
Title (EN) TREATMENT OF HIPPO PATHWAY MUTANT TUMORS AND METHODS OF IDENTIFYING SUBJECTS AS CANDIDATES FOR TREATMENT
(FR) TRAITEMENT DE TUMEURS MUTANTES DE LA VOIE HIPPO ET PROCÉDÉS D'IDENTIFICATION DE SUJETS EN TANT QUE CANDIDATS À UN TRAITEMENT
Abstract: front page image
(EN)The present invention relates to a method of treating a tumor in a subject. This method involves administering to a subject having a Hippo pathway mutant tumor a tankyrase inhibitor, where the tumor is susceptible to treatment with the tankyrase inhibitor, and said administering is carried out to treat the tumor. The present invention also relates to a method of treating cancer in a subject, and a method of identifying a subject as a candidate for treatment.
(FR)La présente invention concerne une méthode de traitement d'une tumeur chez un patient. Cette méthode consiste à administrer à un sujet ayant une tumeur mutante de la voie Hippo un inhibiteur de tankyrase, la tumeur étant sensible au traitement par inhibiteur de la tankyrase, et ladite administration étant réalisée pour traiter la tumeur. La présente invention concerne également une méthode de traitement du cancer chez un sujet, et un procédé d'identification d'un sujet en tant que candidat à un traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)